Abstract
Singlet oxygen (1 O2 ) is widely regarded as the main cytotoxic substance that induces the biological damage for photodynamic therapy (PDT). In this study, the previously developed near-infrared (NIR) optical imaging system was optimized for fast imaging of 1 O2 luminescence. The optical imaging system enables direct imaging of 1 O2 luminescence in blood vessels within 2s during vascular-targeted PDT (V-PDT), which makes this system extremely practical for in vivo studies. The dependence of RB concentration on 1 O2 luminescence image was investigated for V-PDT, and the data imply that 1270nm signal is attributed to 1 O2 luminescence. The imaging system operates with a field of view of 9.60×7.68mm2 and a spatial resolution of 30μm, which holds the potential to elucidate the correlation between cumulative 1 O2 luminescence and vasoconstriction for V-PDT.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
