Abstract
Single-cell transcriptomics: an emerging tool in the study of cardiometabolic disease.
Highlights
The potential for single-cell transcriptomics, the systematic study of the cellular RNA component transcribed by RNA polymerase II, to facilitate research on cellular heterogeneity, disease-specific biomarkers, and networks of expression was recently highlighted in the Journal of Translational Medicine by Zhu et al [1]
Gene-expression profiling of peripheral-blood specimens has been studied as a means of avoiding invasive endomyocardial biopsy in surveillance for rejection after cardiac transplantation or cardiac catheterization in diagnosing obstructive coronary artery disease [2,3]
Single-cell RNA sequencing of bonemarrow-derived dendritic cells after exposure to LPS noted a bimodal distribution of both expression patterns and RNA splicing across populations of seemingly similar cells [11]
Summary
The potential for single-cell transcriptomics, the systematic study of the cellular RNA component transcribed by RNA polymerase II, to facilitate research on cellular heterogeneity, disease-specific biomarkers, and networks of expression was recently highlighted in the Journal of Translational Medicine by Zhu et al [1]. As discussed by Zhu and colleagues, gene expression reflects carefully regulated interactions between genomic DNA, epigenetic modifications, and RNA post-transcriptional modifications. Recent advances in both array- and sequence-based technologies are likely to accelerate application to cardiovascular research.
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