Abstract
A method is proposed to obtain high-resolution 2-D -resolved nuclear magnetic resonance (NMR) spectra in inhomogeneous magnetic fields. The proposed experiment enables the acquisition of an entire 2-D spectrum in a single scan by utilizing intermolecular double-quantum coherences and the spatial encoding of NMR observables. Chemical shifts, coupling constants, and multiplet patterns are recovered even when field inhomogeneities are severe enough to completely obscure conventional NMR spectra. After intentional deshimming to yield inhomogeneous magnetic fields, the method was demonstrated on ethyl 3-bromoproprionate in acetone and on a complex mixture of organic compounds. To illustrate the technique's applicability to biological samples with intrinsic magnetic field inhomogeneities arising from macroscopic magnetic susceptibility variations, we performed the experiment on a pig bone marrow sample. Our results show that the new method is a fast and effective tool for studying complex chemical mixtures and biological tissues. The method could potentially be useful for real-time in vivo NMR studies.
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