Abstract
Abstract. Peroxisome proliferators-activated receptor gamma (PPAR-γ) is thought to play a critical role in glucose and lipid metabolism and in inflammation control. The objective of this study was to detect the single nucleotide polymorphism (SNPs) in whole coding regions of PPAR-gamma gene with single strand conformation polymorphism (SSCP) in Peking duck Z4, Z2, Hybrid and Cherry Valley duck populations. The results showed that there were two alleles and three genotypes in the experimental populations. And one novel polymorphism, a synonymous mutation G-to-T at 213 of 5th exon, was found. The birds with homozygote (TT) was highest for carcass weight, sebum weight, percentage of sebum, abdominal fat weight, percentage of abdominal fat and IMF in four duck populations; however, for breast muscular weight and carcass net weight, the birds with heterozygote (GT) was highest in them. The association analysis results showed that the SNP of the polymorphism of PPAR-γ gene was linked with potential major loci or genes affecting some growth and fatness traits.
Highlights
Intensive selection in duck has made great improvement in growth rate and feed efficiency, modern strains of ducks exhibit excessive body fat deposition
Research showed that the Peroxisome proliferatorsactivated receptors (PPARs)-γ gene has impact on chicken fat metabolism and single nucleotide polymorphism (SNPs) could be used in molecular assistant selection (MAS) as a genetic marker for the chicken fatness traits (LI et al, 2005)
Single Nucleotide Polymorphism in Exon-5 of the PPAR-γ Gene Amplicons of the expected size were obtained from duck DNA using different primers
Summary
Intensive selection in duck has made great improvement in growth rate and feed efficiency, modern strains of ducks exhibit excessive body fat deposition. The economic concern and recognition of consumer aversion to excess fatty tissue deposition have led commercial breeders to incorporate significant selection for reduced body fatness in their breeding programs. Research showed that the PPAR-γ gene has impact on chicken fat metabolism and SNPs could be used in molecular assistant selection (MAS) as a genetic marker for the chicken fatness traits (LI et al, 2005). Up to now, the research about SNPs of the PPAR-γ gene in duck was not reported. The objectives of the present study were to identify SNPs in the duck PPARγ gene and to evaluate associations between the polymorphisms and growth and fatness traits in four duck populations
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