Abstract
Single-molecule mechanical measurements can provide an unprecedented view into the shape, stabilities, and dynamics of biomolecules and their interactions. However, current challenges in determining the spatial arrangement of multiple residues within each molecule with a reasonable resolution and accuracy, have restricted applications. By combining structural DNA nanotechnology with dual-trap optical tweezers, we recently developed a mechanically reconfigurable DNA Nanoswitch Caliper (DNC) capable of measuring multiple distances on single biomolecules with atomic resolution.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
