Abstract
A large-scale single-cell RNA-seq analysis of tumor-associated macrophages in gliomas has unveiled a new aspect of the complex tumor microenvironment and new biomarkers.
Highlights
Tumor heterogeneity is determined by both heterogeneous tumor cells and a complex tumor microenvironment
The binary ontogeny model versus the continuum model of macrophages Tumor-associated macrophages (TAMs) are abundant in gliomas and evidence suggests that these TAMs
The data show a significant increase in blood-derived TAMs, but not in microglial TAMs, in glioblastoma compared to low-grade glioma (Fig. 5a in [8])
Summary
Tumor heterogeneity is determined by both heterogeneous tumor cells and a complex tumor microenvironment. The binary ontogeny model versus the continuum model of macrophages Tumor-associated macrophages (TAMs) are abundant in gliomas and evidence suggests that these TAMs This distinct pattern indicates different underlying mechanisms in low-grade glioma and glioblastoma.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
