Abstract
BackgroundCancer is widely believed to result from chronic inflammation, and red cell distribution width (RDW) and mean platelet volume (MPV) are considered as inflammatory markers for cancer. We investigated the values of RDW, MPV, and cancer antigen 125 (CA125), alone or in combination, for distinguishing between ovarian cancer and benign ovarian tumors.MethodsThe study included 326 patients with ovarian cancer, 290 patients with benign ovarian tumors, and 162 control subjects. Hematologic tests were performed at initial diagnosis.ResultsRDW was increased and MPV was decreased in the ovarian cancer group compared with the control and benign ovarian tumor groups. RDW was positively correlated and MPV was negatively correlated with cancer stage. Area under the curve (AUC) analysis for ovarian cancer versus benign ovarian tumors revealed that the specificity and sensitivity were increased for the combination of MPV and CA125 compared with either marker alone, and the specificity was increased for the combination of RDW and CA125, compared with either alone. The AUCs for RDW plus CA125 and MPV plus CA125 were significantly larger than for any of the markers alone.ConclusionsIn conclusion, combinations of the markers RDW, MPV, and CA125 may improve the differential diagnosis of ovarian cancer and benign ovarian tumors.
Highlights
Cancer is widely believed to result from chronic inflammation, and red cell distribution width (RDW) and mean platelet volume (MPV) are considered as inflammatory markers for cancer
RDW and MPV levels in patients with ovarian cancer or benign ovarian tumors and in healthy individuals are shown in Figs. 1 and 2
The results of the current study showed that RDW levels were significantly higher and MPV levels were significantly lower in patients with ovarian cancer compared with patients with benign ovarian tumors and healthy controls
Summary
Cancer is widely believed to result from chronic inflammation, and red cell distribution width (RDW) and mean platelet volume (MPV) are considered as inflammatory markers for cancer. We investigated the values of RDW, MPV, and cancer antigen 125 (CA125), alone or in combination, for distinguishing between ovarian cancer and benign ovarian tumors. The ovaries are located in the pelvic cavity and are relatively concealed, in addition to which early ovarian cancer lacks any obvious clinical manifestations and diagnostic methods, making it difficult to diagnose early and to distinguish from benign ovarian tumors. The red cell volume distribution width (RDW) is a quantitative parameter indicating the size of the red blood cells. RDW reflects red cell volume heterogeneity and is usually measured as part of the whole blood cell count.
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