Abstract
AbstractBackgroundThe SINGapore GERiatric intervention study to reduce physical frailty and cognitive decline (SINGER) is a pilot study, aiming to evaluate culturally appropriate adaptations of the FINGER interventions, and the feasibility of implementing this protocol in 70 seniors, aged >65 years, with mild‐to‐moderate frailty and/or cognitive impairment over a 6‐month period (Table). The main outcome of this pilot study is the feasibility of and adherence to the multidomain intervention as concerns have been raised particularly for the dietary and cognitive interventions which could require novel and culturally appropriate approaches. We aim to develop scalable digital platforms and build partnerships so as to conduct a larger definitive study in 1200 elderly community dwelling Singaporeans who are at risk for cognitive impairment and dementia. This larger study comparing self‐guided lifestyle management versus a structured multidomain lifestyle intervention will also incorporate neuroimaging and blood biomarkers so as to investigate mechanisms of action.
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