Abstract
Background In the last years the number of melanoma patients has increased markedly. High plasma levels of interleukin-6 (IL-6) are associated with bad prognosis and reduction in overall survival of these patients. Statins, HMG-CoA reductase inhibitors, are well-tolerated therapeutics for hypercholesterolemia. We have recently shown that simvastatin triggers apoptosis in 518A2 human melanoma cells which is paralleled by concentration-dependent changes in autocrine IL-6 secretion. Here, we investigated the impact of simvastatin on the IL-6 pathway.
Highlights
In the last years the number of melanoma patients has increased markedly
We have recently shown that simvastatin triggers apoptosis in 518A2 human melanoma cells which is paralleled by concentration-dependent changes in autocrine IL-6 secretion
Increasing concentrations of simvastatin led to enhanced surface expression of the IL-6-R and the gp130 subunit
Summary
In the last years the number of melanoma patients has increased markedly. High plasma levels of interleukin-6 (IL-6) are associated with bad prognosis and reduction in overall survival of these patients. HMG-CoA reductase inhibitors, are well-tolerated therapeutics for hypercholesterolemia. We have recently shown that simvastatin triggers apoptosis in 518A2 human melanoma cells which is paralleled by concentration-dependent changes in autocrine IL-6 secretion. We investigated the impact of simvastatin on the IL-6 pathway
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