Abstract
The measurement of intima-media thickness (IMT) of carotid arteries has emerged as the method of choice for determining the anatomic extent of atherosclerosis and assessing cardiovascular progression. Statins are used in the primary and secondary prevention of cardiovascular and cerebrovascular disorders so as to reduce morbidity and mortality. To evaluate the effects of treatment with simvastatin in patients with elevated cholesterol levels and increased values of carotid arteries IMT. The study of 275 patients (155 male and 115 female, aged 37-79 years, mean 60.86 years) was performed from January 2008 - January 2010 at the Vascular and Endovascular Surgery Clinic of the Clinical Centre of Serbia. All patients were treated with simvastatin administered once a day for 6 months. Simvastatin treatment resulted in a statistically signuficant decrease of the IMT thickness of the right common carotid artery. There was no statistically significant reduction in the IMT of the left common carotid artery as well as in the IMT of the right and left internal carotid arteries. Long-term simvastatin treatment results in the regression or slowing down atherosclerosis in symptomatic, as well as in asymptomatic patients with a lower grade of carotid stenosis (IMT below 2.5 mm).
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
