Abstract
BackgroundLeptomeningeal metastasis (LM) is a predominantly late stage, devastating complication of a variety of malignant solid tumors. Diagnosis relies predominantly on neurological, radiographic, and cerebrospinal fluid (CSF) assessments. Recently, liquid biopsy tests derived from CSF has shown to be a feasible, noninvasive promising approach to tumor molecular profiling for proper brain cancer diagnostic treatment, thereby providing an opportunity for CSF-based personalized medicine. However, LM is typically misleadingly assumed to originate from only one primary tumor type.Case presentationIn this case report, we provide first evidence of the co-occurrence of LM originating from more than one primary tumor types.Discussion and conclusionsBased on this patient case profile, the co-occurrence of LM from two or more primary tumor types should be accounted for when deriving diagnostic conclusions from liquid biopsy tests.
Highlights
Leptomeningeal metastasis (LM) is a predominantly late stage, devastating complication of a variety of malignant solid tumors
Based on this patient case profile, the co-occurrence of LM from two or more primary tumor types should be accounted for when deriving diagnostic conclusions from liquid biopsy tests
Case presentation We describe the case of a 65-year-old Caucasian female with recurrent focal aware seizures (FAS; known as simple partial seizures) who exhibited motor dysfunction of the right arm and leg as well as symptoms of nausea, Stoppek et al BMC Cancer (2019) 19:995 regurgitation, and deafness in October of 2017
Summary
Leptomeningeal metastasis (LM) is a predominantly late stage, devastating complication of a variety of malignant solid tumors. Discussion and conclusions: Based on this patient case profile, the co-occurrence of LM from two or more primary tumor types should be accounted for when deriving diagnostic conclusions from liquid biopsy tests.
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