Abstract
Plasma concentrations of 170H-progesterone (17P), testosterone (T) and saliva concentrations of 17P have been determined serially for 3 yr in 16 treated CAH patients with 21-hydroxylase deficiency (present age 4.0-16.5 yr) . Analysis of 71 paired samples showed significant correlations between plasma 17P and T (r=0.70,p 0.1) , presumably because of the marked individual variation in the adrenal suppressive effect of glucocorticoid. The ease of saliva collection permitted 24-hour home 17P profiles in treated patients. All demonstrated a marked diurnal rhythm, but well-controlled patients showed normal 17P levels during the afternoon. Frequent serial measurements of 17P through saliva collection at home is an additional simple and useful parameter for fine-tuning control in CAH patients.
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