Abstract
RESULTS: Overexpression of the DTL protein was detected in ESCC cell lines (4/13 cell lines; 30%) and primary ESCC tumor samples (19/76 cases; 25%). Knockdown of DTL using several specific siRNAs inhibited the proliferation, migration and invasion of DTL-overexpressing cells in a TP53 mutation-independent manner. Overexpression of the DTL protein was significantly correlated with a pathological lymph node metastasis. DTL-overexpressing tumors had a worse overall rate of survival than non-DTL-expressing tumors (p1⁄40.003). In a multivariate analysis, DTL positivity was independently associated with a worse outcome following curative resection (p1⁄40.025, hazard ratio 2.61 [1.13-5.93]).
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