Abstract
A fast, simple, specific, and accurate stability indicating liquid chromatographic method is described for simultaneous determination of piroxicam and paracetamol in bulk drugs and pharmaceutical formulations. Optimum chromatographic separations among the piroxicam, paracetamol, and stress-induced degradation products were achieved within 6 min by using a Hypersil BDS C8 column as stationary phase with acetonitrile and 0.02 M phosphate buffer pH 3.0 (60:40, v/v) as the mobile phase at a flow rate of 1.0 mL min−1 with detection using a diode array detector at 254 nm. ICH guidelines were used to validate the developed method. Linearity was from 1.6–6.4 µg mL−1 for piroxicam and 26–104 µg mL−1 for paracetamol. All the analytes including the degradation products were separated with acceptable peak tailing and resolution. The peak purity index for both the analytes after all types of stress is >0.999, indicating complete separation of both analytes peaks from the stress induced degradation products. The developed method can be successfully used for simultaneous determination of piroxicam and paracetamol in pharmaceutical formulations and stability studies.
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