Abstract
A flow injection analysis (FIA) and multiple pulse amperometric detection (MPA) using a cathodically pretreated boron-doped diamond electrode (CPT-BDD) were employed for simultaneous determination of the antihypertensive drugs hydrochlorothiazide (HTZ) and enalapril (ENP). A dual-potential waveform as a function of time, previously optimized, was used: Edet.1=+1.50V/150ms (pulse potential at which HTZ was oxidized) and Edet.2=+1.80V/150ms (pulse potential at which oxidation of both analytes – HTZ and ENP – occurs). The analytical curves presented good linearity from 0.40 to 8.00μmolL−1 for HTZ and from 0.03 to 1.00μmolL−1 for HTZ, and the detection limits were 0.20μmolL−1 for HTZ and 0.01μmolL−1 for ENP. The proposed flow method presented an analytical frequency of 89 determinations per hour, good precision and accuracy, was successfully applied to the simultaneous determination of HTZ and ENP in pharmaceutical samples and the results obtained using the FIA–MPA method were in agreement with those obtained using a comparative method (HPLC) at a 95% confidence level.
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