Abstract
ABSTRACT The efficacy of concomitant administration of metformin and Cnidoscolus aconitifolius (Chaya) teas in type 2 diabetic rat models was evaluated. Diabetic rats were treated for 28 days with metformin and infusions of green (GTC) and black (BTC) chaya teas. Total phenol and flavonoid contents, as the antioxidant capacities of tea infusions, were assessed. Fasting blood glucose (FBG), lipid profile and markers of hepatic and renal functions were assessed. GTC exhibited the highest phenolic and flavonoid contents, as the best antioxidant activities. Daily co-administration of GTC and BTC with metformin significantly (p < .05) lowered the FBG, triglyceride, total cholesterol, LDL cholesterol, ALT, AST, creatinine and urea, as well as a significant increase in the serum protein. The combination of Chaya tea infusions with metformin treatment performed better than metformin taken alone in regulating fasting blood glucose in diabetic rats, with the best results observed in the group receiving GTC infusion.
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