Abstract
Abstract Simple and efficient synthesis of a novel fused bicyclic heterocyclic compound 3 by the reaction of ethyl 2-cyano-3,3-bis(methylthio)acrylate and thiourea in the presence of potassium carbonate in dimethylformamide under reflux conditions is reported. The optimized molar ratio of the substrates is 2:1. The parent compound was used for further derivatization by using a synthetic strategy that is based on suitability of the substituted pyrimido[2,1-b][1,3]thiazine system to react as a bis-electrophilic species with various nucleophiles. Products 4a–e and 5a–e were obtained in good yields (65–76%).
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