Abstract
AbstractA new guanidine‐based magnetic nanocatalyst was prepared according to a three‐step operationally simple process using simple, cheap and readily‐available chemicals. Guanidine as the organocatalytic center was covalently attached to amino‐functionalized magnetic nanoparticles via cyanuric chloride as a cross‐linking agent. The developed nanocatalyst was employed efficiently for the one‐pot, four‐component synthesis of polyhydroquinolines as the medicinally important polycyclic heterocycle compounds in water according to a convenient catalytic procedure. The nanocatalyst could be magnetically separated from the reaction mixture and reused for several times. The reaction profile was very clean and only 0.2 mol% of catalyst is needed to obtain products in excellent yields at very short reaction times according to an easy work‐up procedure.
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