Abstract
The main disadvantage of the implants is the associated infections. Therefore, in the long term, the possibility of improving the antibacterial capacity of different types of implants (dental, orthopedic) is being researched. The severity of the problem lies in the increasing bacterial resistance and finding appropriate alternative treatments for infectious diseases, which is an important research field nowadays. The purpose of this review is to draw a parallel between different studies analyzing the antibacterial activity and mechanism of silver nanoparticles (NP Ag) deposited on the titanium nanotubes (NTT), as well as the analysis of the NP Ag toxicity. This review also provides an overview of the synthesis and characterization of TiO2-derived nanotubes (NT). Thus, the analysis aims to present the existing knowledge to better understand the NP Ag implants benefits and their antibacterial activity.
Highlights
Titanium, together with its alloys, is one of the most used elements in orthopedic and dental applications due to its biocompatibility, mechanical properties, and corrosion resistance [1]
It is known that titanium-based alloys are used to manufacture medical appliances, such as artificial blood vessels and orthopedic/dental implants [2]
This review provides an overview of TiO2 -derived NT synthesized by various methods, and its antimicrobial activity, obtained by incorporating NTT with suitable agents such as ions of Ag
Summary
Together with its alloys, is one of the most used elements in orthopedic and dental applications due to its biocompatibility, mechanical properties, and corrosion resistance [1]. It is known that titanium-based alloys are used to manufacture medical appliances, such as artificial blood vessels and orthopedic/dental implants [2]. The causes of implant rejection may still be unknown and impossible to predict preoperatively. One of the leading causes of implant rejection is an immune system imbalance and a combination of bacterial infection with adverse reactions of the immune system [3,4]. Because of the increasing bacterial resistance to antimicrobial agents, infections are often difficult to treat even with specific antibiotics, increasing the risk of mortality and morbidity [5]. Several types of microorganisms (bacteria, viruses, parasites, and fungi) can cause bone infections [6]
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