Abstract
Silicalite-1 is a purely siliceous form of zeolite, which does not contain potentially harmful aluminum in its structure as opposed to ZSM-5 aluminosilicate types of zeolite. This paper reports on a study of a silicalite-1 film, deposited on a silicon Si(100) substrate, as a potential anti-corrosive and biocompatible coating for orthopaedic implants. Silicalite-1 film was prepared in situ on the surface of Si(100) wafers using a reaction mixture of tetrapropyl-ammonium hydroxide (TPAOH), tetraethyl-orthosilicate (TEOS), and diH2O. The physico-chemical properties of the obtained surface were characterized by means of X-ray photoelectron spectroscopy, water contact angle measurement, atomic force microscopy, and scanning electron microscopy. The biocompatibility was assessed by interaction with the MG-63 cell line (human osteosarcoma) in terms of cell adhesion, morphology, proliferation, and viability. The synthesized silicalite-1 film consisted of two layers (b- and a, b-oriented crystals) creating a combination of micro- and nano-scale surface morphology suitable for cell growth. Despite its hydrophobicity, the silicalite-1 film increased the number of initially adhered human osteoblast-like MG-63 cells and the proliferation rate of these cells. The silicalite-1 film also improved the cell viability in comparison with the reference Si(100) substrate. It is therefore a promising candidate for coating of orthopaedic implants.
Highlights
Materials for the fabrication of orthopaedic implants have to withstand high loads while retaining corrosion and wear resistance, chemical stability, and biocompatibility with the host tissues and body fluids
The concentrations of carbon (C), nitrogen (N), oxygen (O) and silicon (Si) in the surface region of the silicalite-1 film (SF) were estimated from the integral intensities of C 1s, N 1s, O 1s and Si 2p photoelectron lines corrected for the probability of photoemission [28]
Results of of characterization of of were identical as as those recently published forfor anan analogous sample silicalite-1 film grown polished surface of stainless steel
Summary
Materials for the fabrication of orthopaedic implants have to withstand high loads while retaining corrosion and wear resistance, chemical stability, and biocompatibility with the host tissues and body fluids. Metals and metallic alloys are most frequently used for this purpose, as they exhibit suitable mechanical properties for load-bearing applications. Some metals and metallic alloys release potentially harmful ions, such as Cr, Co, Ni, Al, or V [1], caused by wear of the implant at the bone–implant interface. A wide range of approaches to surface modification, including various implant coatings, have been investigated in recent years in order to obtain a more chemically stable, corrosion-and wear-resistant, and biocompatible surface, while retaining the suitable mechanical properties of the bulk material.
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