Abstract
The elucidation of molecular and signaling pathways in eukaryotic cells is often achieved by targeting regulatory element(s) found in the promoter or the enhancer region of eukaryotic gene(s) using a double-stranded (ds) oligodeoxynucleotide (ODN) containing a specific cis-element. Our laboratory is focusing on dsODN decoys containing the TGF-beta element as a novel nonsteroidal antifibrotic for achieving normal wound healing. In the model systems discussed, there is either a specific gene possessing a specific cis-element or a cluster of genes with one gene containing the consensus cis-element. The rest of the genes in the cluster contain the cis-elements homologous to this consensus element, which allows for dsODN decoy regulation of a gene cluster at one time.
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