Abstract
PURPOSE: Some patients with advanced heart failure develop severe pulmonary hypertension (PH). Impaired reactivity of pulmonary bed to vasodilator challenge with PGE1 or with other vasodilators significantly predicts poor heart transplant (Tx) outcome. Testing of PH reversibility is therefore used for selection of Tx candidates. The aim of our study was to compare the effects of PGE1, an agent mostly used at our institution, with novel potent pulmonary vasodilator – sildenafil citrate on hemodynamics in patients with chronic heart failure and severe PH.
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