Abstract
Darier's disease, also known as keratosis follicularis or Darier-White disease, is an autosomal dominant inherited condition. The disease usually has its onset in the teenage years, meaning it co-exists with the years of fertility in women. The potential dermatological and obstetric implications of Darrier's Disease, especially when it involves the groin and vulva, have not been well reported. We report a case of Darier's Disease associated with multiple antibiotic resistant folliculitis involving skin of the breasts, groin, vulva and perineum that precluded safe vaginal delivery.
Highlights
Xenon has been considered an ideal anaesthetic agent due to rapid induction and emergence of anaesthesia, efficient analgesia, and low toxicity [1,2]
Data suggest that blockade of NMDA receptors in the nervous system by xenon plays a key role in neuroprotective effects of this agent [5,8,9,10]
NMDA receptors have been found in the axons of human skin [15] and in the keratinocytes of the epidermis [16,17]
Summary
Xenon has been considered an ideal anaesthetic agent due to rapid induction and emergence of anaesthesia, efficient analgesia, and low toxicity [1,2]. Data suggest that blockade of NMDA receptors in the nervous system by xenon plays a key role in neuroprotective effects of this agent [5,8,9,10]. NMDA receptors have been found in the axons of human skin [15] and in the keratinocytes of the epidermis [16,17]. These receptors are involved in skin barrier function [18], calcium regulation [19], and dermatitis development [20]. We expect that xenon will exert similar blocking action when interacting with NMDA receptors in skin providing that this gas penetrates skin
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