Abstract
Epidemiological investigations have shown that patients with Parkinson’s disease (PD) have a lower probability of developing lung cancer. Subsequent research revealed that PD and lung cancer share specific genetic alterations. Therefore, the utilisation of PD biomarkers and therapeutic targets may improve lung adenocarcinoma (LUAD) diagnosis and treatment. We aimed to identify a gene-based signature from 25 Parkinson family genes for LUAD prognosis and treatment choice. We analysed Parkinson family gene expression and protein levels in LUAD, utilising multiple databases. Least absolute shrinkage and selection operator (LASSO) regression was used to construct a prognostic model based on the TCGA-LUAD cohort. We validated the model in external GEO cohorts. Immune cell infiltration was compared between risk groups, and GEO data was used to explore the model’s predictive ability for LUAD treatment response. Nearly all Parkinson family genes exhibited significant differential expression between LUAD and normal tissues. LASSO regression confirmed that our seven Parkinson family gene-based signature had excellent prognostic performance for LUAD, as validated in three GEO cohorts. The high-risk group was clearly associated with low tumour immune cell infiltration, suggesting that immunotherapy may not be an optimal treatment choice. This is the first Parkinson family gene-based model for the prediction of LUAD prognosis and treatment outcome. The association of these genes with poor prognosis and low immune infiltration requires further investigation.
Highlights
Parkinson’s disease (PD) is the most common neurodegenerative motor disorder
In order to explore the expression of Parkinson family genes in lung adenocarcinoma (LUAD), we obtained the normalised cancer and normal tissue gene expression data of LUAD patient samples from the the Cancer Genome Atlas (TCGA) and Genotype-Tissue Expression Project (GTEx) databases in UCSC Xena
We found that 12 genes had significant differences based on LUAD prognosis (Figures 2A,B)
Summary
Parkinson’s disease (PD) is the most common neurodegenerative motor disorder. It develops as a result of the premature death of dopamine-containing neurons in a part of the midbrain called the substantia nigra. This leads to a loss of dopaminergic neurons within the substantia nigra pars compacta, depletion of dopamine in the striatum, and the presence of Lewy bodies (Jankovic, 2008). Parkinson Genes in LUAD Prognosis and lung cancer has been gradually revealed. The intriguing overlap of genes implicated in these two completely different diseases suggests that studying these genes may help improve lung cancer diagnosis, prognosis, and treatment
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
