SIGNIFICANCE OF LEPTIN LEVEL IN ASSESSMENT OF ADAPTIVE IMMUNITY

Abstract

Adipokine leptin is produced by the adipose tissue in quantities directly proportional to its mass. It is well known as a regulator of energy exchange, which provides control of energy consumption and expenditures. New information becomes available about its participation in control of some other physiological functions including functioning of immune competent cells. We have determined parameters of the immune status and concentration of leptin in blood plasma in 37 healthy volunteers aged 22-24 years living in Arkhangelsk. All volunteers had physical activity in gym 2-3 times a week, their body mass index fell in the normal range corresponding to the interval 19.5 - 23.8. We have studied the association of leptin concentration with concentration of immune competent cells and cytokines in blood. It has been found that quantitative differences in the leptin level directly corresponded to the changes of concentration of lymphocytes expressing receptors CD3, CD4, CD8, CD10, CD25, CD71, CD95, HLADR, while the amount of CD23+ cells and IL-4 concentration was changed in the opposite way. We have also determined the character of changes in leptin and cytokines TNF-α and IFN-γ concentrations blood. Using the normalized varimax rotation algorithm, we have built a three-factor model that described satisfactorily the association between leptin and T-lymphocytes' phenotypes, constituting its pleiotropic effect on T-cell subsets.