Abstract
IT appears increasingly certain that vascular interfacial phenomena are critically involved in the development of intravascular thrombosis. However, comments on the role of the vessel wall in the maintenance of vascular homoeostasis are conspicuously absent in discussions of the subject. In a recent article by Macfarlane1 it was suggested that foreign surfaces activate Factor XII, triggering the cascade of reactions involved in ‘physiologic clotting’. A series of experiments in this laboratory, including measurement of transmural ion fluxes2, absorption and concentration of various important anions and cations by vessel wall cells and fibres3,4, and measurement of the zeta potential in the electric double layer at the blood-intimal interface as shown by both electro-osmosis5 and streaming potential6 experiments, indicate that charge on the vessel wall is important in vascular homoeostasis.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
