Abstract
Single-pixel imaging geometries for wide-field multiphoton microscopy (SPx-MPM) have emerged as a contender to conventional point-scanning multiphoton systems (PS-MPM) for deep tissue imaging. These systems are thought to be faster due to their multiplexed imaging capabilities with higher photon throughput. In this study we numerically compare the signal to noise metrics of the SPx-MPM to the PS-MPM systems. Our results suggest that PS-MPM systems outperform SPx-MPM systems, despite their higher photon throughput.
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