Abstract
The sigma1 receptor is an integral membrane protein of ~26kD which shares no structural homology with any traditional receptor family. Sigma1 binding sites are highly conserved across mammalian species and are present in a broad range of tissue, with particularly high expression in distinct regions of the CNS. Given the CNS expression of sigma1 receptors and the neuro‐active properties of many sigma1 receptor ligands, we hypothesize that sigma1 receptors may play a role in neuronal differentiation. Differentiating neuroblastoma cells upregulates sigma1 receptors, with high levels in distinct vesicular structures throughout neurite outgrowths in contrast to an endoplasmic reticulum distribution in undifferentiated cells. These data suggest an association of sigma1 receptors with neuronal differentiation.Funded by grants to GWP (DA0641, DA02615 and DA00220) from the National Institute of Drug Abuse
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