Abstract
Sickle cell Anemia with avascular necrosis of femur being managed as rheumatic fever
Highlights
Sickle cell anemia, though a common medical problem in Africa and many other parts of the world. is a rare hematological problem in Nepal and described only in the forms of case reports
Patients who are homozygous for the hemoglobin S (HbS) gene have fullblown sickle cell anemia
Its an autosomal recessive disease resulting from the substitution of valine for glutamic acid at position 6 of the betaglobin gene, leading to production of a defective form of hemoglobin, hemoglobin S (HbS)
Summary
Though a common medical problem in Africa and many other parts of the world. is a rare hematological problem in Nepal and described only in the forms of case reports. Is a rare hematological problem in Nepal and described only in the forms of case reports. Though a common medical problem in Africa and many other parts of the world. It is an autosomal recessive genetic disease that results from the substitution of valine for glutamic acid at position 6 of the beta-globin gene, leading to production of a defective form of hemoglobin, hemoglobin S (HbS). The clinical manifestations of sickle cell anemia are diverse, and any organ system may be affected. These manifestations commonly are divided into vasoocclusive, hematologic, and infectious crises
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