Abstract
The elimination of obesity is essential to maintaining good health. Medium-chain triglycerides (MCTs) inhibit fat accumulation. However, studies examining energy expenditure and fat oxidation with continuous ingestion of MCTs show little association with the elimination of obesity. In this study, we conducted a randomized, double-blind crossover clinical trial to investigate the effects of continuous ingestion of MCTs on postprandial energy expenditure and ingested long-chain triglycerides (LCTs) oxidation. A daily 2 g of MCTs were ingested for two weeks by sedentary participants with a body mass index (BMI) from 25 (kg/m2) to less than 30. Ingestion of a meal containing MCTs and isotopic carbon-13-labeled (13C) LCTs increased energy expenditure and consumption of diet-derived LCTs, as determined by postprandial 13C carbon dioxide excretion, compared to canola oil as the placebo control. These results indicate that continuous ingestion of MCTs could enhance postprandial degradation of diet-derived fat and energy expenditure in sedentary, overweight individuals.
Highlights
Obesity is well-known as a risk factor for metabolic diseases such as hypertension, dyslipidemia, and type 2 diabetes [1–3]
We investigated the beneficial effect of medium-chain triglycerides (MCTs) on postprandial ingested fat consumption, which could be involved in the elimination of obesity
The results showed that the continuous ingestion of MCTs significantly enhanced postprandial consumption of diet-derived fat, compared to canola oil
Summary
Obesity is well-known as a risk factor for metabolic diseases such as hypertension, dyslipidemia, and type 2 diabetes [1–3]. One of the energy-producing nutrients, have been shown to have varying effects on obesity, depending on the types of fatty acids [6]. Research on the alternative use of long-chain fatty acids started mainly on fatty acids with a chain length of 8 carbon atoms (octanoic acid, C8) and 10 carbon atoms (decanoic acid, C10) [7,9]. This was followed by research on biological regulatory functions different from those of long-chain fatty acids, one of which was research on the elimination of obesity [10,11]
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