Short-term effects of maternal oxygen administration on blood flow velocity waveforms in healthy and growth-retarded fetuses

Abstract

To determine whether maternal oxygen administration affects fetal hemodynamics, we investigated 10 healthy fetuses and 10 growth-retarded fetuses near term by means of Doppler ultrasonography. The growth-retarded fetuses were characterized by abnormal blood flow velocity waveforms. Velocity waveforms were simultaneously recorded at 5-minute intervals from the fetal descending aorta and internal carotid artery before, during, and after maternal oxygen administered through a face mask that delivered 60% oxygen. The pulsatility index was calculated. During oxygen treatment growth-retarded fetuses showed significant temporary hemodynamic modifications as expressed by changes of pulsatility index values that increased in the internal carotid artery and decreased at the level of the descending aorta. On the other side no changes were found in healthy fetuses. These findings suggest that maternal oxygen administration can modify fetal hemodynamics in cases of growth retardation associated with abnormal blood flow velocity waveforms.