Abstract
Mice fed a protein deficient diet containing 2% ovalbumin were renourished with a diet containing 20% ovalbumin for the final 4 or 8 days of a 6 week diet feeding period. The effect of this short term renourishment on the IgM and IgA immune response after oral immunization with sheep red blood cells was determined as the number of plaque forming cells (PFC) in the spleen. Both renourishment intervals resulted in a significant increase in body weight. Mice renourished for 4 days had a significantly enhanced IgA PFC response as compared to mice fed the low protein diet only. Mice renourished for 8 days had an even greater IgA PFC response and also had an enhanced number of IgM PFC. These responses were also significantly higher than previously reported values for the IgA and IgM PFC of mice fed the control diet for 6 weeks. These results indicate that the immune response to a mucosally encountered antigen recovers very quickly with renourishment, even to the extent of allowing an enhanced rebound of the PFC response.
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