Abstract
Acute myocardial infarction (AMI) has been a preclinical and clinical concern due to high hospitalization rate and mortality. This study was aimed at evaluating the effectiveness and safety of Shexiang Baoxin Pill (SBP) for AMI and exploring the possible mechanism of oxidative stress. Six databases were searched on March 26, 2021. Twenty-four studies were included and accessed by the RoB 2.0 or SYRCLE tool. Compared with routine treatment (RT), SBP showed the effectiveness in the clinical efficacy (RR = 1.15, 95% CI [1.06, 1.25]), left ventricular ejection fraction (LVEF) (SMD = 0.73, 95% CI [0.62, 0.95]), glutathione (GSH) (SMD = 2.07, 95% CI [1.51, 2.64]), superoxide dismutase (SOD) (SMD = 0.92, 95% CI [0.58, 1.26]), malondialdehyde (MDA) (SMD = −4.23, 95% CI [-5.80, -2.66]), creatine kinase-myocardial band (CK-MB) (SMD = −4.98, 95% CI [-5.64, -4.33]), cardiac troponin I (cTnI) (SMD = −2.17, 95% CI [-2.57, -1.76]), high-sensitivity C-reactive protein (Hs-CRP) (SMD = −1.34, 95% CI [-1.56, -1.12]), interleukin-6 (IL-6) (SMD = −0.99, 95% CI [-1.26, -0.71]), triglycerides (TG) (SMD = −0.52, 95% CI [-0.83, -0.22]), flow-mediated dilation (FMD) (SMD = 1.39, 95% CI [1.06, 1.72]), von Willebrand Factor (vWF) (SMD = −1.77, 95% CI [-2.39, -1.15]), nitric oxide (NO) (SMD = 0.89, 95% CI [0.65, 1.13]), and recurrent rate (RR = 0.30, 95% CI [0.15, 0.59]). But SBP adjunctive to RT plus PCI had no improvements in almost pooled outcomes except for the Hs-CRP (SMD = −1.19, 95% CI [-1.44, -0.94]) and TG (SMD = −0.25, 95% CI [-0.48, -0.02]). Laboratory findings showed that SBP enhanced the endothelial nitric oxide synthase (eNOS) activity and regulated laboratory indexes especially for homocysteine. In conclusion, SBP has adjunctive effects on AMI via the mechanism of antioxidative stress. The current evidence supports the use of SBP for mild and moderate AMI patients.
Highlights
Acute myocardial infarction (AMI) is the sudden damage to the myocardium due to insufficient blood flow to the heart
The current evidence supports the use of Shexiang Baoxin Pill (SBP) for mild and moderate AMI patients
The analysis showed that SBP plus routine treatment (RT) had a higher level of nitric oxide (NO) compared with RT alone (SMD = 0:89, 95% CI [0.65, 1.13], p < 0:05; Q ð2Þ = 0:15, p = 0:93, I2 = 0, low heterogeneity) (Figure 5(f))
Summary
Acute myocardial infarction (AMI) is the sudden damage to the myocardium due to insufficient blood flow to the heart. It is characterized by chest pain, chest discomfort, and acute shortness of breath [1]. AMI has become the leading cause of hospitalization and death [2]. Revascularization and primary percutaneous coronary intervention (PCI) restore blood flow to the culprit coronary artery and reduce AMI mortality rate [3, 4]. Immediate multivessel PCI might cause additional risks, e.g., induction of further ischemia, volume overload, and renal impairment due to the use of an increased dose of contrast material [5, 6]. Prevention of I/R injury in AMI could reduce the injury
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
