Abstract

HighlightsFOXO3 was decreased, while LA and FBXO22 were increased in NSCLC patients.LA promoted cisplatin resistance in NSCLC in vitro and in vivo.SQFZ inhibited LA-induced cisplatin resistance in NSCLC by regulating FOXO3.FBXO22 affected p53 ubiquitination to reverse the inhibitory effect of SQFZ.SQFZ inhibited cisplatin resistance in NSCLC by FOXO3/FBXO22/p53 axis.

Talk to us

Join us for a 30 min session where you can share your feedback and ask us any queries you have

Schedule a call

Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.