Abstract
Abstract The mechanism of action of sex steroid hormones (SHs), androgen (A) or oestrogen (E), on the protein kinase C (PKC)-related signal transduction pathway was examined in culture of a rat thymus epithelial cell line (TEC; IT-45R1). The results were as follows: (a) proliferation of TEC in response to SHs is mediated by plasma membrane-associated signal pathways generated as a result of interactions between SHs and plasma-borne inhibitors; (b) the action of cyclins and cyclin-dependent families, such as cdc2/cdk2 kinases, play a key role in cell cycle progression in TEC; (c) the SH-induced `shutoff' effect on TEC cell proliferation is triggered by high doses of SHs. These results clearly suggest that `non-genomic' SH action is a crucial event for TEC proliferation, and that TEC proliferation is controlled by a `shutoff' mechanism triggered by high levels of SHs. The development of the TEC network in the thymus was discussed in relation to this `shutoff' mechanism.
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