Abstract
The interrelations of circannual rhythms of the functional states of pineal gland, hypothalamo-pituitary-adrenal axis, and thymus in healthy 20–79-year-old men and women were studied. Fluctuations of melatonin, ACTH, cortisol, and serum thymic factor that are characteristic of young 20–29-year-old people changed with aging (changes of amplitudes of seasonal peaks of hormones, shift of the seasonal acrophase, monotony). Rhythmicity disorder of studied organs in men was observed earlier than in women (pineal gland and ACTH of hypophysis after 30; thymus and adrenal cortex after 40) and more prominent. The age-specific desynchronosis of melatonin production in the pineal gland is an important pathogenetic part in disturbance of rhythmicity of hypothalamo-pituitary-adrenal system and thymus.
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