Sex Differences in the Gene Expression Profile of LOX‐1 in Mouse Tissues

Abstract

Lectin‐like oxidized low‐density lipoprotein receptor‐1 (LOX‐1) is recognized as an important cardiovascular cell scavenger receptor for oxidized low‐density lipoproteins (oxLDL). LOX‐1 activation mediates several oxLDL‐stimulated intracellular signaling pathways and tissue processes that lead to oxidative stress, inflammatory cell infiltration in the vessel wall, endothelial dysfunction, and cardiovascular pathophysiology. In the current study, we analyzed the gene expression profiles of LOX‐1 in the aortas, hearts, liver, lungs, and kidneys of male and female C57BL/6J mice. Significant sex differences were observed in LOX‐1 mRNA expression. LOX‐1 mRNA levels were higher in male mouse aortas and hearts compared with female tissues. Conversely, LOX‐1 gene expression was elevated in female versus male kidneys. In mouse liver and lungs, we found LOX‐1 mRNA levels were comparable in males and females. These results clearly suggest that significant sex differences exist in the gene expression profiles of LOX‐1 in mouse tissues, and given the data supporting the tissue‐specific differences in LOX‐1 gene expression between males and females, we speculate these studies will provide new insights into the cellular mechanisms directly responsible for the critical, sex‐linked roles of LOX‐1 in both vascular dysfunction and other disease complications.Support or Funding Information(Supported by 5K12HD043451).