Abstract
Summary1. Force-feeding of purified choline-containing diets devoid of methionine for 3 to 6 days induces fatty liver in adult female rats, but not in adult male rats. Excess lipid accumulates in the periportal region of liver lobule. 2. Force-feeding of threonine-devoid diet for 3 days to adult rats also induces periportal fatty liver but without a sex difference. 3. Occurrence of the same sex difference and the same lobular distribution of fat in the liver by force-feeding methionine devoid diets and by injection of ethionine lends further support to the thesis that ethionine exerts some of its effects through interfering with metabolic role of methionine. 4. Since choline does not protect liver against the effects of methionine deficiency, it appears that methionine must play some role in regulation of lipid content of liver aside from its contribution of methyl groups for synthesis of choline. It is suggested that this role of methionine is related in some as yet unknown manner with the action of andr...
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
More From: Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.