Abstract
200 mg/kg of Metopirone (2- methyl-1, 2-bis-(3-pyridyl)-l-propanone; Su-4885) was administered to intact male and female rats perorally once daily for 30 days with 1% sodium chloride solution to drink. Systolic blood pressure of female rats was elevated to a greater degree and more constantly than that of male rats. Metopirone caused in female rats a fall in adrenal vein corticosterone which was greater than that which occurred in male rats. In addition, Metopirone caused a secretion of deoxycorticosterone which lasted 16 hr in female rats but no longer than 8 hr in male rats. Metopirone was found in peripheral plasma obtained at 16 hr after peroral administration in female rats but not in male rats. Biological half-time of Metopirone was 120 min for female rats and 49 min for male rats. There were found at least 3 metabolites of Metopirone in peripheral blood. Combined levels of the metabolites at 30 min after peroral administration were higher in male rats than in female rats. From these findings it was...
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