Severe polyneuritis following gold therapy for rheumatoid arthritis.

Abstract

Case Reports1 December 1950SEVERE POLYNEURITIS FOLLOWING GOLD THERAPY FOR RHEUMATOID ARTHRITISJOHN B. DOYLE, M.D., F.A.C.P., ESPEY F. CANNON, M.D.JOHN B. DOYLE, M.D., F.A.C.P.Search for more papers by this author, ESPEY F. CANNON, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-33-6-1468 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe use of gold salts continues to be a mainstay in the treatment of rheumatoid arthritis. This is so despite the well-known dangers of toxicity of these compounds, and the fact that their use is still on a purely empirical basis. In view of their highly probable therapeutic value, the employment of these drugs is justifiable if due regard is given to the danger of their use.Recent observations would indicate that BAL1, 2, 3may prove a safe and effective means of counteracting serious complications. A case of severe polyneuritis occurring in the course of therapy of rheumatoid arthritis...Bibliography1. CohenGoldmanDubbs AJAW: The treatment of acute gold and arsenic poisoning; use of BAL (2.3 dimercaptopropanol, British Anti-Lewisite), J. A. M. A. 133: 749-752 (Mar. 15) 1947. CrossrefMedlineGoogle Scholar2. RaganBoots CRH: The treatment of gold dermatitides; use of BAL (2.3 dimercaptopropanol), J. A. M. A. 133: 752-754 (Mar. 15) 1947. CrossrefMedlineGoogle Scholar3. LockieNorcrossGeorge LMBMCW: Treatment of two reactions due to gold; response of thrombopenic purpura and granulocytopenia to BAL therapy, J. A. M. A. 133: 754-755 (Mar. 15) 1947. CrossrefMedlineGoogle Scholar4. BlockKnapp WDEL: The effect of various gold compounds on the oxygen consumption of rat tissues, J. Pharmacol. and Exper. Therap. 83: 275-278 (April) 1945. Google Scholar5. BlockBuchananFreyberg DHRH: A comparative study of the distribution and excretion of gold following the intramuscular injection of five different gold compounds, J. Pharmacol. and Exper. Therap. 73: 200-204 (Oct.) 1941. Google Scholar6. BlockBuchananFreyburg DHRH: Studies of the absorption, distribution and excretion of gold following the injection of gold thioglucose and gold calcium thiomalate, J. Pharmacol. and Exper. Therap. 76: 355-357 (Dec.) 1942. Google Scholar7. SteinerFischl GV: Quoted by Lescher, Nervous complications following treatment by gold salts, Brit. M. J. 2: 1303-1305 (Dec. 26) 1936. CrossrefMedlineGoogle Scholar8. Hench PS: Gold salts for rheumatoid arthritis, Ann. Int. Med. 26: 618-624 (April) 1947. LinkGoogle Scholar9. Sundelin F: Die Goldbehandlung der chronischen Arthritis unter besonderer Berucksichtigung der Komplikationen, Acta med. Scandinav. Supp. 117: 1-291, 1941. Google Scholar10. Lescher C: Nervous complications following treatment by gold salts, Brit. M. J. 2: 1303-1305 (Dec. 26) 1936. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication November 16, 1948. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byConcomitant rheumatoid arthritis and amyotrophic lateral sclerosis: report of two new cases and review of literatureAutometallographic detection of gold in dorsal root ganglia of rats treated with sodium aurothiomalateSystemic gold therapyRheumatic syndromes caused by antirheumatic drugsHeavy Metal NeuropathiesAtrioventricular conduction time in rheumatoid arthritisNeurologic complications induced by gold treatmentGold toxicity presenting as peripheral neuropathyThe Guillain Barre Syndrome Following Gold TherapyGold toxicity and peritoneal dialysisRHEUMATISM AND ARTHRITIS REVIEW OF AMERICAN AND ENGLISH LITERATURE OF RECENT YEARS (ELEVENTH RHEUMATISM REVIEW)* Part IIWILLIAM D. ROBINSON, M.D., F.A.C.P., JOSEPH J. BUNIM, M.D., F.A.C.P., WILLIAM S. CLARK, M.D., DARRELL C. CRAIN, M.D., F.A.C.P., EPHRAIM P. ENGLEMAN, M.D., F.A.C.P., DONALD C. GRAHAM, M.D., F.R.C.P. (C), MAX M. MONTGOMERY, M.D., F.A.C.P., BERNARD M. NORCROSS, M.D., F.A.C.P., CHARLES RAGAN, M.D., F.A.C.P., MARIAN W. ROPES, M.D., F.A.C.P., EDWARD F. ROSENBERG, M.D., F.A.C.P., CHARLEY J. SMYTH, M.D., F.A.C.P.Rheumatoid arthritis: A review of recent advances in our knowledge concerning pathology, diagnosis, and treatmentGOLD THERAPY FOR RHEUMATOID ARTHRITIS: A CURRENT EVALUATION*W. GRAFTON HERSPERGER, M.D., F.A.C.P. 1 December 1950Volume 33, Issue 6Page: 1468-1472KeywordsDrugsRheumatoid arthritisSaltsToxicity ePublished: 1 December 2008 Issue Published: 1 December 1950 PDF downloadLoading ...