Abstract
IntroductionLeukocytoclastic vasculitis (also known as hypersensitivity vasculitis and cutaneous necrotizing vasculitis) can present with various manifestations, which often delays the diagnosis and treatment. In order to show the importance of the early recognition of leukocytoclastic vasculitis, we present a case which occurred secondary to the use of a common pharmaceutical, naproxen. We were unable to find a case of leukocytoclastic vasculitis secondary to naproxen in the literature.Case presentationWe present the case of a 33-year-old African American woman with below the knee and bilateral digital gangrene from hypersensitivity vasculitis secondary to the non-steroidal anti-inflammatory medication naproxen.ConclusionThis is an original case report focusing on the rheumatologic management of leukocytoclastic vasculitis. However, other specialties, such as internal medicine, dermatology, infectious disease, general surgery and pathology, can gain valuable information by reviewing this case report. Reporting a case of leukocytoclastic vasculitis secondary to treatment with naproxen will advance our understanding of this disease etiology by adding yet another non-steroidal anti-inflammatory drug to the list of potential causes of leukocytoclastic vasculitis.
Highlights
Leukocytoclastic vasculitis can present with various manifestations, which often delays the diagnosis and treatment
This is an original case report focusing on the rheumatologic management of leukocytoclastic vasculitis
Reporting a case of leukocytoclastic vasculitis secondary to treatment with naproxen will advance our understanding of this disease etiology by adding yet another nonsteroidal anti-inflammatory drug to the list of potential causes of leukocytoclastic vasculitis
Summary
We have presented an atypical case of leukocytoclastic vasculitis in a 33-year-old African American woman secondary to the use of naproxen resulting in multi-limb ischemia and subsequent amputation. Adding yet another pharmaceutical to the list of potential causes of leukocytoclastic vasculitis will significantly add to our understanding of the etiology of this disease. We reiterate that amputation in this scenario was an unfortunate and debilitating last resort once all therapeutic modalities failed to improve her gangrene This is an original case report of particular interest to rheumatology. Additional file 1 American College of Rheumatology criteria for hypersensitivity vasculitis.
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