Abstract
SummarySevere intrahepatic cholestasis occurred in 12 young females taking regularly oral contraceptives, 2–20 days after the intake of triacetyloleandomycin (TAO). Severe itching and jaundice lasted for 12–14 weeks. The pronounced increase in serum bilirubin contrasted sharply with the moderate increase in alkaline phosphatase levels. The gamma-glutamyltranspeptidase activities were normal or only slightly elevated, as has been found usually in women taking oral contraceptives. The liver biopsy taken in one patient showed a pure cholestasis. The combined intake of TAO and oral contraceptives is incriminated as toxic phenomena occur rarely when the drugs are taken separately. Indeed TAO seems to block the further metabolism of oestrogens. It is felt that oral contraceptives are a contraindication for treatment with TAO.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
