Abstract
Since January 2018, over 53,000 hospitalisations and six deaths due to hand, foot and mouth disease (HFMD) have occurred across Vietnam with most cases from September onward. In a large tertiary referral hospital, Ho Chi Minh City, enterovirus A71 subgenogroup C4 was predominant, while B5 was only sporadically detected. The re-emergence of C4 after causing a severe HFMD outbreak with > 200 deaths in 2011–12 among susceptible young children raises concern of another impending severe outbreak.
Highlights
Since January 2018, over 53,000 hospitalisations and six deaths due to hand, foot and mouth disease (HFMD) have occurred across Vietnam with most cases from September onward
Our aim was to characterise the epidemiology, virology and clinical characteristics of patients, especially those with severe HFMD, through an ongoing clinical study conducted at a large tertiary referral hospital for children in Ho Chi Minh City, Vietnam from January to September 2018
In contrast to HFMD associated with other serotypes, the burden of enterovirus A71 (EV-A71) is attributed to both large numbers of hospitalised cases and a relatively high proportion of cases with severe disease and case fatality
Summary
Citation style for this article: Nhan Le Nguyen Thanh, Hong Nguyen Thi Thu, Nhu Le Nguyen Truc, Nguyet Lam Anh, Ny Nguyen Thi Han, Thanh Tran Tan, Han Do Duong Kim, Van Hoang Minh Tu, Thwaites C Louise, Hien Tran Tinh, Qui Phan Tu, Quang Pham Van, Minh Ngo Ngoc Quang, van Doorn H. Khanh Truong Huu, Chau Nguyen Van Vinh, Thwaites Guy, Hung Nguyen Thanh, Tan Le Van. Severe enterovirus A71 associated hand, foot and mouth disease, Vietnam, 2018: preliminary report of an impending outbreak. Our aim was to characterise the epidemiology, virology and clinical characteristics of patients, especially those with severe HFMD, through an ongoing clinical study conducted at a large tertiary referral hospital for children in Ho Chi Minh City, Vietnam from January to September 2018
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