Abstract
This chapter describes the identification of lyase/dRpase activities in mitochondrial polymerase γ/and ligase; it also examined the substrates for mitochondrial (mt)DNA repair, as well as the cell specific differences and biological consequences of mtDNA repair; and Bohr examined oxidative DNA damage repair in mtDNA and the correlation of increased repair capacity with age. Mitochondrial DNA does not code for any DNA damage processing enzymes, but only for the oxidative phosphorylation proteins and some transfer (t)RNAs. Thus, all repair enzymes functioning in the mitochondria need to be transported in.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Progress in Nucleic Acid Research and Molecular Biology
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
