Abstract
ObjectiveWe assessed the correlation between serum carbohydrate antigen 125 (CA125) and carotid intima-media thickness (cIMT) in patients with coronary artery disease (CAD).MethodsWe collected 518 CAD patients from the cardiovascular disease center in our hospital, and all cIMT values were measured in patients with CAD.ResultsThe serum CA125 concentrations were found to be increased in CAD patients with early carotid atherosclerosis compared with patients without early carotid atherosclerosis (20.1±7.72 vs. 17.7±6.41 U/mL, p<0.001). The cIMT values were increased in patients with higher serum CA-125 levels than those with lower serum CA-125 concentrations (1.16±0.32 vs. 0.98±0.29 mm, p<0.001). There was a positive correlation between serum CA125 and cIMT in CAD patients (r=0.262, p<0.001). Moreover, the serum CA125 concentrations also were positively correlated with cIMT in subjects with early carotid atherosclerosis and without early carotid atherosclerosis (r=0.255, p<0.001; r=0.189, p=0.002). We found that serum CA-125 concentrations were independently correlated with cIMT (beta = 0.293, p<0.001) in multiple linear regression analysis.ConclusionsWe found that serum CA125 concentrations were positively correlated with cIMT in CAD patients, serum CA125 might be a potential biochemical marker for the estimation of atherosclerosis in patients with CAD.
Highlights
Fast plasma glucose (FPG), total protein (TP), alanine aminotransferase (ALT), aspartate aminotransferase (AST), triglyceride (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C) levels were tested by using automatic biochemistry analyzer
When the concentrations of serum CA 125 were divided by the median, the carotid intima-media thickness (cIMT) values were increased in patients with higher serum CA-125 levels than those with lower serum
In the multiple linear regression analysis, adjustment for sex, age, body mass index (BMI), blood glucose, LDL-C,HDL-C, TC, TG, High-sensitivity C-reactive protein (hs-CRP), ALT, AST, diabetes mellitus, hypertension and medications uses, we found that serum CA-125 concentrations were independently correlated with cIMT in multiple linear regression analysis (Table 3)
Summary
We collected 518 CAD patients from the cardiovascular disease center in the First Affiliated Hospital, Xinjiang. The diagnosis of CAD was determined by coronary angiography in all patients. Patients with following conditions were excluded: liver dysfunction, chronic obstructive pulmonary disease, aortic dissection, immune diseases, acute and chronic infections, malignant tumor and psychosis. The study was approved by the ethics committee of the First Affiliated Hospital, Xinjiang Medical University. We collected information about physical examinations such as age, gender, body mass index (BMI) and drug use histories. Fast plasma glucose (FPG), total protein (TP), alanine aminotransferase (ALT), aspartate aminotransferase (AST), triglyceride (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C) levels were tested by using automatic biochemistry analyzer. High-sensitivity C-reactive protein (hs-CRP) concentrations were tested by automatic immune analyzer.
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