Abstract
<p>This study was designed to understand whether the post-menopausal Chinese women (n=175) receiving tablet containing vitamin D (500 IU) and calcium (500 mg) had lower incidence of bone fracture compared to the post-menopausal Chinese women ((n=175) receiving a diet rich in calcium, vitamin D, and protein (milk, cheese, and yogurt, soybeans, spinach, fish including fatty fish, cheese, egg). This study assessed whether the levels of serum osteocalcin and urinary free deoxypyridinoline could be used as predictors of early bone trauma during post-menopausal period. After randomization, subjects were followed-up for up to 3 years to capture required data. The results suggested that therapeutic intervention (vitamin D and calcium) does not predict bone fracture among the post-menopausal Chinese women. However, correlation analysis revealed that the decreased level of serum osteocalcin and urinary free deoxypyridinoline were associated with higher incidence of fracture. The results suggest that the low level of serum osteocalcin and urinary free deoxypyridinoline cause increase susceptibility of fracture among the post-menopausal Chinese women.</p>
Highlights
Osteoporosis is one of the leading causes of morbidity and becoming a major public health problem worldwide and its prevalence is increasing
It was noted that the levels of serum osteocalcin and urinary free deoxypyridinoline were significantly lesser in sub-group who had higher incidence of bone trauma/fracture, irrespective of therapeutic intervention
It has been observed that the levels of serum osteocalcin (11.1 vs. 29.1 ng/mL) and urinary free deoxypyridinoline (4.1 vs. 9.4 ng/mL) were significantly lesser in subject who experienced bone trauma/fracture as compared to subject with no bone trauma/fracture during study period (Table II)
Summary
Osteoporosis is one of the leading causes of morbidity and becoming a major public health problem worldwide and its prevalence is increasing. It has been reported that the higher levels of bone formation and resorption markers are significantly associated with higher bone mineral density loss. In clinical studies, it appears that markers of bone resorption may be useful predictors of fracture risk and bone loss. The association of markers of bone resorption with hip fracture risk in adults is independent of bone mineral density, but a low bone mineral density combined with high bone resorption biomarker may increases the risk of bone fracture/trauma. Bone turnover markers may have a future role in the clinical management of osteoporosis
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