Abstract
Objective: To determine serum concentrations and 24-hour urinary excretion of nitrate (NO3-), the stable bioreaction product of nitric oxide, in patients with severe septic shock and renal failure, in patients with chronic renal failure and in healthy controls. Design: Prospective study. Setting: Intensive care units at Ulleval University Hospital and Akershus Central Hospital, Oslo, Norway. Patients: Seven patients admitted with severe septic shock and renal failure, six patients undergoing chronic ambulatory haemodialysis (CAHD) for end-stage kidney disease and six healthy volunteers for serum NO 3 determination. Twenty-four-hour urinary NO3- excretion on a low nitrate diet was also studied in six healthy volunteers. Interventions: Daily serum sampling was performed without any study interventions. Volunteers were given a low nitrate diet (NO3- intake <6 mg/24 hr) during urine sampling to determine the basal 24-hour urine excretion of NO3-. Measurements and main results: NO3- was determined by ion ch...
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