Abstract

Endotoxin was administered intravenously to five normal subjects.Measurement of serum neopterin levels demonstrated no significant change from baseline during the first 6 h after endotoxin administration, but were elevated two to four-fold at 24 h.In the three subjects in whom it was measured, a two-fold rise of the mean serum neopterin levels persisted at 48 h.The acute inflammatory events initiated by endotoxin administration to normal humans result in a delayed, but sustained, rise in serum neopterin levels which persists well after the acute phase response has subsided.

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