Serum level of orexin-A, leptin, adiponectin and insulin in north Indian obese women

Abstract

Background and aimsObesity is regulated by different metabolic factors like leptin, adiponectin insulin and neuropeptide orexin-A. The aim of this study is to assess the role of these hormones and their interrelationship with obesity in north Indian women. MethodA total of 168 obese women with Body Mass Index (BMI)>30kg/m2 and 150 lean women (BMI<25kg/m2) as control were recruited in this study. Women with obesity were further subdivided into two groups according to their BMI, 71 overweight women with the BMI 25–29.9kg/m2 (mean±S.D: 27.87±0.71) and the 97 obese women with BMI>30kg/m2 (34.68±1.90). Orexin −A, leptin and adiponectin were estimated using quantitative sandwich enzyme linked immunoassay and insulin was estimated by using an immuno-radiometric assay. ResultOrexin −A and adiponectin level were significantly lower however, leptin and inulin level were significantly higher in obese women as compared with control group. Further, the one- way group analysis showed that the orexin −A and adiponectin level were significantly lower but leptin and insulin level was significantly higher in obese women as compared to overweight and control group respectively. ConclusionResult showed that the level of adiponectin, leptin, orexin-A and insulin play an important role in the regulation of energy expenditure. In obesity, the activity of these peptides is disturbed.