Abstract
ABSTRACTObjective:In view of the side effects of voiding cystourethrography (VCUG), identification of noninvasive markers predicting the presence of vesicoureteral reflux (VUR) is important. This study was conducted to determine the predictive value of serum interleukin-8 (IL-8) in diagnosis of VUR in children with first febrile urinary tract infection (UTI).Materials and Methods:Eighty children with first febrile UTI were divided into two groups, with and without VUR, based on the results of VCUG. The sensitivity, specificity, positive and negative predictive value positive and negative likelihood ratio, and accuracy of IL-8 for prediction of VUR were investigated.Results:Of the 80 children with febrile UTI, 30 (37.5%) had VUR. There was no significant difference between the children with and without VUR and also between low and high-grade VUR groups in terms of serum concentration of IL-8 (P>0.05). Based on ROC curve, the sensitivity, specificity, likelihood ratio positive, and accuracy of serum IL-8 was lower than those of erythrocyte sedimentation rate and C-reactive protein. Multivariate logistic regression analysis showed significant positive correlation only between erythrocyte sedimentation rate and VUR.Conclusions:This study showed no significant difference between the children with and without VUR in terms of the serum concentration of IL-8. Therefore, it seems that serum IL-8 is not a reliable marker for prediction of VUR.
Highlights
Urinary tract infection (UTI) is a common disease in children
It seems that serum IL-8 is not a reliable marker for prediction of vesicoureteral reflux (VUR)
Urinary tract infection occurs in three forms: acute pyelonephritis, cystitis, and asymptomatic bacteriuria
Summary
Urinary tract infection (UTI) is a common disease in children. Its prevalence in male and female children is 1% and 3-8%, respectively [1]. Urinary tract infection occurs in three forms: acute pyelonephritis, cystitis, and asymptomatic bacteriuria. Acute pyelonephritis is the most severe type of the disease. The lack of early diagnosis and appropriate treatment result in dangerous complications, such as renal scarring [2, 3]. The prevalence of renal scarring is 18-49% [2, 4,5,6,7]
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